Abstract
Intracellular free Ca 2+ and Na + concentrations in cultured rat dorsal root ganglion cells were studied using the intracellular fluorescent probes fura-2 and SBFI, respectively. Capsaicin increased both intracellular [Ca 2+] and [Na +]. A rise in cytosolic free Ca 2+ could still be seen if Na + was removed from the outer medium. The results suggest that capsaicin opens up ion channels which are permeable both to Ca 2+ and Na +.
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