Abstract
Intraarterial administration of chemotherapy results in augmentation of both local peak plasma concentration of the drug and local area under the concentration - times - time curve (AUC) during the drug infusion (1–4). It can be particularly advantageous to administer drugs with a rapid total body clearance intraarterially since if clearance is rapid, the usual AUC will be relatively small, and the local increase in AUC resulting from intraarterial administration will be proportionally quite large (3, 4). For some drugs, intraarterial administration would be expected to result in increased therapeutic efficacy, while for other drugs, there would be relatively little advantage (1–4). Augmentation of local tissue concentrations by intraarterial administration has been documented for some drugs (5–9), but not for others (10).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
