Abstract
Background and Objective The effect of temporarily interrupted hepatic blood flow and multiple-fiber application on necrosis volume in interstitial laser coagulation (ILC) was investigated. Study Design/Materials and Methods: Single- and multiple-fiber ILC were performed in porcine livers with normal as well as interrupted perfusion. Temperatures were determined. Lesions were measured and studied by light microscopy 4 hours post-treatment. Results ILC with multiple-fiber application led to significantly greater individual lesion volumes (3.7 ± 0.5 cm3) than single-fiber application (2.5 ± 0.5 cm3) (P < .01). The interruption of hepatic perfusion led to a significant increase in lesion volume with single- (7.5 ± 1.0 cm3) as well as multiple-fiber application (12.6 ± 2.2 cm3) (P < .01). Superposition of the lesions in the multiple-fiber application mode was only determined with interrupted perfusion (total volume: 50.3 ± 6.6 cm3). Conclusion Interruption of hepatic perfusion increases lesion volumes significantly. ILC for treating liver tumors should preferably be performed by application routes that permit temporary interruption of hepatic perfusion. Lasers Surg. Med. 23:40–47, 1998. © 1998 Wiley-Liss, Inc.
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