Abstract
Interstitial Cells of Cajal and the Promise of Single Cell Molecular Analysis
Highlights
The electrical activity of ICC originates from the interplay between pumps and channels, generating their oscillating pacemaker activity
When the GI tract suffers from pathological insults, the ICC network is disrupted and the number of ICC in the intestine diminishes
“orphan” conductances that have not a particular gene associated to them. Such is the case of the maxi channel, which has proven elusive to identify as shown by knockdown studies performed in fibroblasts [18]
Summary
The electrical activity of ICC originates from the interplay between pumps and channels, generating their oscillating pacemaker activity. When the GI tract suffers from pathological insults, the ICC network is disrupted and the number of ICC in the intestine diminishes.
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