Abstract
When weanling rats were fed purified diets with added cholesterol and cholic acid for 20 weeks, the blood cholesterol levels of females were two to three times higher than those of males. This effect was greatest when the diet contained a severely hypercholesterolemic fat (coconut oil), and least with cottonseed oil; lard was intermediate. Intermittent vitamin B6 deficiency eliminated the sex difference in blood cholesterol in rats fed the hypercholesterolemic diets; the values for males increased, whereas the values for females decreased to a point where the sex difference was not significant. Coconut oil in the diet, especially combined with a vitamin B6 deficiency, caused marked liver cirrhosis, enlarged adrenals, kidney damage and nodules and hyperplasia in the stomach, as well as a pronounced increase in sudanophilic lesions in the aorta.
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