Abstract
IntroductionSurvival from oesophageal cancer remains poor, even across high-income countries. Ongoing changes in the epidemiology of the disease highlight the need for survival assessments by its two main histological subtypes,...
Highlights
Survival from oesophageal cancer remains poor, even across high-income countries
While oesophageal cancer survival has been increasing across countries in recent years, it remains low for both disease subtypes
The disease is predominantly categorised by two main histological subtypes with distinct aetiologies: adenocarcinoma (AC), which is typically located in the lower third of the oesophagus and linked to Barrett’s oesophagus, and squamous cell carcinoma (SCC), which develops in the native oesophageal epithelium
Summary
Ongoing changes in the epidemiology of the disease highlight the need for survival assessments by its two main histological subtypes, adenocarcinoma (AC) and squamous cell carcinoma (SCC). Methods: The ICBP SURVMARK-2 project, a platform for international comparisons of cancer survival, collected cases of oesophageal cancer diagnosed 1995-2014, followed until 31st December 2015, from cancer registries covering seven participating countries with similar access to health care (Australia, Canada, Denmark, Ireland, New Zealand, Norway and the UK). Survival was consistently higher for both subtypes in Australia and Ireland followed by Norway, Denmark, New Zealand, the UK and Canada. Less marked improvements 3 years after diagnosis, among older age groups and patients with SCC, highlight the need for further advances in early detection and treatment of oesophageal cancer alongside primary prevention to reduce the overall burden from the disease. Positron emission tomography computed tomography (PET-CT) scanning has been found to improve staging of oesophageal cancer and this has provided better guidance for stage-specific treatment.[9]
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