Abstract
Background: Intermittent Theta Burst Stimulation (iTBS) is a design of repetitive Transcranial Magnetic Stimulation (rTMS) and could be a candidate to replace rTMS in the treatment of depression, thanks to its efficacy, shorter duration, and ease of use. The antidepressant mechanism of iTBS, and whether this mechanism is mediated by a modulation of cortical excitability, remains unknown.Methods: Using a randomized double-blind, sham-controlled trial, 30 healthy volunteers received either iTBS or a sham treatment targeting the left DorsoLateral PreFrontal Cortex (L-DLPFC), twice a day over 5 consecutive days. Cortical excitability was measured before and after the 5 days of stimulation.Results: No difference in cortical excitability was observed between active or sham iTBS.Conclusion: Our study does not support any effect on cortical excitability of repetitive iTBS targeting the L-DLPFC.
Highlights
Repeated Transcranial Magnetic Stimulation is a validated non-invasive brain stimulation technique used to treat resistant depression [1].Intermittent Theta Burst Stimulation is a design of rTMS that uses a very highly modulated frequency to produce a high number of pulses in a shorter time
Our study does not support any effect on cortical excitability of repetitive Intermittent Theta Burst Stimulation (iTBS) targeting the L-DorsoLateral PreFrontal Cortex (DLPFC)
This study is a randomized double-blind vs. placebo trial designed to assess cortical excitability in the motor cortex before and after ten sessions of iTBS over the L-DLPFC
Summary
Intermittent Theta Burst Stimulation (iTBS) is a design of rTMS that uses a very highly modulated frequency to produce a high number of pulses in a shorter time. This increases cortical excitability in a more robust and longer lasting way than rTMS, and in a similar way to High-Frequency (HF) rTMS [2]. Intermittent Theta Burst Stimulation (iTBS) is a design of repetitive Transcranial Magnetic Stimulation (rTMS) and could be a candidate to replace rTMS in the treatment of depression, thanks to its efficacy, shorter duration, and ease of use. The antidepressant mechanism of iTBS, and whether this mechanism is mediated by a modulation of cortical excitability, remains unknown
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