Abstract
Sinonasal polyposis (SNP) is a chronic inflammatory pathology of the nasal/paranasal cavities which affects from 1%-4% of the population. Although polyps seem to be a manifestation of chronic inflammation of nasal/paranasal sinus mucosa in both allergic and non-allergic subjects, the pathogenesis of nasal polyposis remains unknown. Interleukin-17A (IL-17A) is a key inflammatory cytokine in many disorders. Little attention has been paid to the role of IL-17A in chronic inflammatory disorders. ObjectiveTo investigate the expression of IL-17A in the SNP and verify if this expression is a marker of good or bad prognosis. MethodProspective study with 25 patients presenting with SNP were subjected to the immunohistochemistry technique. After a skin prick test, all patients were divided into atopic and nonatopic groups, and asthmatic or non-asthmatic. ResultsThe IL-17A expression was observed in both atopic and nonatopic patients. The numbers of IL-17A positive cells were greater in nasal polyps of atopic patients than nonatopic (p = 0.0128). ConclusionThese results indicate that IL-17A may play an important role in the pathology of SNP. Considering the inflammatory properties of IL-17A, this study suggests that it could increase susceptibility to atopy and asthma.
Highlights
Sinonasal polyposis (SNP) or chronic rhinosinusitis with nasal polyps is a chronic inflammatory pathology of the nasal and paranasal cavities[1,2], which affects from 1% to 4% of the population and has a clear association with asthma, aspirin sensitivity and cystic fibrosis[3].Patients with SNP typically present with nasal obstruction, rhinorrhea, hyposmia and reduced quality of life[3,4]
These results indicate that IL-17A may play an important role in the pathology of SNP
Patients without sinonasal polyposis identified in the computed tomography (CT) scan and nasal endoscopy were excluded from this study
Summary
Sinonasal polyposis (SNP) or chronic rhinosinusitis with nasal polyps is a chronic inflammatory pathology of the nasal and paranasal cavities[1,2], which affects from 1% to 4% of the population and has a clear association with asthma, aspirin sensitivity and cystic fibrosis[3].Patients with SNP typically present with nasal obstruction, rhinorrhea, hyposmia and reduced quality of life[3,4]. Sinonasal polyposis (SNP) or chronic rhinosinusitis with nasal polyps is a chronic inflammatory pathology of the nasal and paranasal cavities[1,2], which affects from 1% to 4% of the population and has a clear association with asthma, aspirin sensitivity and cystic fibrosis[3]. Polyps seem to be a manifestation of the chronic inflammation of nasal/paranasal sinus mucosa in both allergic and non-allergic subjects, the pathogenesis of nasal polyposis remains unknown[5,6], but it is probably a multifactorial disease with several different etiological factors, and chronic persistent inflammation is undoubtedly a major factor irrespective of the etiology[5]. Despite the major impact on quality of life[7], in the literature there are no concerns about biomarkers involved in the pathogenesis of nasal polyps and their possible contributions to the prognosis of SNP
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