Abstract
Meeting abstracts Myxoma virus, a rabbit poxvirus, can efficiently infect various classes of mouse and human cancer cells. It is a strict rabbit-specific pathogen, safe to use in all non-rabbit hosts tested including mice and humans. Recombinant viruses were previously engineered to express
Highlights
Myxoma virus, a rabbit poxvirus, can efficiently infect various classes of mouse and human cancer cells
IL15 is an immunomodulatory cytokine with a great potential for stimulating T lymphocytes and NK cells
Our previous studies have shown that earlier generation recombinant myxoma viruses selectively infected tumors, but had limited therapeutic effect in vivo
Summary
A rabbit poxvirus, can efficiently infect various classes of mouse and human cancer cells. Interleukin-15 (IL-15) and IL-15 receptor alpha fusion protein enhances antitumor activity of myxoma virus Recombinant viruses were previously engineered to express tdTomatoRed fluorescent protein (vMyx-tdTr) and mouse interleukin-15 (vMyx-IL15-tdTr).
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