Interleukin -10, Lactic Acid Dehydrogenase, Total Protein, Albumin and Globulin in Infected Women with Toxoplasmosis

Abstract

Objective: The aim of the study was to identify biomarkers in women diagnosed with Toxoplasmosis. Materials and Methods: The study was conducted between February 2022 and March 2023, and it focused on detecting Toxoplasma gondii in 100 female patients with a history of repeated abortion, aged between 18 and 43 years. The patients receiving treatment were present at two educational hospitals located in Baghdad. The diagnosis was established through the utilization of Immunochromatography and ELISA techniques. Blood samples were gathered from every individual, along with 30 healthy controls matched for age. The study measured the concentrations of Interleukin-10, Lactic acid Dehydrogenase, Total protein, Albumin, and Globulin in the patients' and controls' sera. Results: The findings revealed that 45 cases exhibited the presence of anti-Toxoplasma IgG, while 76 cases displayed the presence of anti- Toxoplasma IgM, out of the 100 women with a history of abortion and Toxoplasma infection. This was determined using immunochromatography methods, on the other hand, utilizing the ELISA methods, anti-Toxoplasma IgG was detected in 40 cases, and anti-Toxoplasma IgM was detected in 42 cases. Conclusions: The findings revealed elevated levels of IL- 10, Lactic acid Dehydrogenase, Total protein, and Globulin in the patients' sera, along with decreased levels of Albumin compared to the healthy controls.