Abstract
Interleukin-1 is present in the central nervous system (CNS) during acute and chronic pathological processes. In the present study, we examined the interaction between recombinant human interleukin-1β (rhIL-1β) and the voltage-dependent calcium (Ca 2+) current using the whole-cell patch clamp technique. RhIL-1β depressed the voltage-gated Ca 2+ current in acutely dissociated guinea pig hippocampal CA1 neurons. This depression is rapid and is observed at pathophysiological concentrations (⩾ 1.97 pg/10 μl)- Concomitant application of rhIL-1β and rhIL-1 receptor antagonist had no effect indicating neuroactive specificity of rhIL-1β. The depression of the inward Ca 2+ current by IL-1β may play a role in: 1. 1) the regulation of neuronal excitability; 2. 2) the induction of neurological manifestations during disease; and 3. 3) in the induction and/or progression of neurodegenerative processes.
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