Intergenerational Gender Preferences in Romantic Partner Selection: An Indonesian Perspective

In an attempt to study the relationship between sleep postures and sleep parameters assessed by actigraphy, we applied the newly developed Activity Monitoring and Evaluation System (A-MES) and actigraphy at the same time to younger and senior Japanese volunteer groups. It was found that sleep postures and diurnal activity determines, to some extent, sleep parameters including activity mean score (AMS), activity index (ACTX), waking episodes (WEP) and sleep fragmentation index (SFX). It was also found that sleep properties are different in younger and senior Japanese. For example, increase in the proportion of time in the supine position resulted in enhancement and deterioration of the sleep in the younger and senior groups, respectively. Furthermore, there were correlations between supine posture and AMS, ACTX, SFX, total minutes scored as awake (TMSA) and WEP obtained by actigraphy in the younger group, but only AMS and ACTX in senior group. In addition, we also assessed sleep parameters by use of questionnaires, and found that objective sleep quality was rather poor but subjective sleep quality was better in the senior group. In the younger group, in contrast, objective sleep quality was better but subjective sleep quality was poor. On the other hand, there was no correlation between sleep parameters assessed by actigraphy and self-report at all. The present study with A-MES and actigraphy provides the first evidence that sleep posture affects sleep quality and is a convenient, inexpensive and home-based method for studying sleep.

Limb girdle muscular dystrophy (LGMD) 2A/R1, caused by mutations in the CAPN3 gene and CAPN3 loss of function, is known to play a role in disease pathogenicity. In this study, AAVrh74.tMCK.CAPN3 was delivered systemically to two different age groups of CAPN3 knockout (KO) mice; each group included two treatment cohorts receiving low (1.17 × 1014 vg/kg) and high (2.35 × 1014 vg/kg) doses of the vector and untreated controls. Treatment efficacy was tested 20 weeks after gene delivery using functional (treadmill), physiological (in vivo muscle contractility assay), and histopathological outcomes. AAV.CAPN3 gene therapy resulted in significant, robust improvements in functional outcomes and muscle physiology at low and high doses in both age groups. Histological analyses of skeletal muscle showed remodeling of muscle, a switch to fatigue-resistant oxidative fibers in females, and fiber size increases in both sexes. Safety studies revealed no organ tissue abnormalities; specifically, there was no histopathological evidence of cardiotoxicity. These results show that CAPN3 gene replacement therapy improved the phenotype in the CAPN3 KO mouse model at both doses independent of age at the time of vector administration. The improvements were supported by an absence of cardiotoxicity, showing the efficacy and safety of the AAV.CAPN3 vector as a potential gene therapy for LGMDR1.

The analysis of the circadian rhythm of heart rate variability (HRV) represents a relevant physiological tool to assess the vagal system. However, the influence of age (mostly >75 years) on HRV is not widely known. The aim of this study was to evaluate the influence of age on HRV, particularly in the elderly and to identify a model of this relationship. The study was carried out by examining linear and nonlinear parameters extracted from HRV, including individuals over 75 years for which there is no research available. Data from 140 healthy subjects were sex matched and divided into young (young group: 15-39 years old), adult (adult group: 40-64 years old) and senior (senior group: 65-90 years old) groups. 24-h Holter monitoring was used and several HRV parameters were extracted from time, and spectral and nonlinear analyses were examined. Time-domain parameters, mainly standard deviation of the NN interval (SDNN) and number of successive differences of intervals which differ by more than 50 ms, presented significant differences between the young group and the other two groups during the 24-h period, while normalized spectral parameters (LFn, HFn and low frequency/high frequency), as well as nonlinear parameters, mainly β exponent and fractal dimension, showed significant difference between the senior group and the other two groups. All these parameters showed a similar circadian rhythm with significant differences between the mean day and night values, especially in young and adult group cohorts. Moreover, a parabolic relationship between these parameters and age was highlighted with an opposite trend over about 60 years compared with younger people. A progressive physiological autonomic imbalance is present in ageing. The inverse trend in the relation between HRV parameters and age found in the senior group could be mainly due to a faster fluctuation of RR. This should be considered when studying changes in the cardiac autonomic nervous control.

With the aggravation of the aging society, the proportion of senior is gradually increasing. The brain structure size is changing with age. Thus, a certain of researchers focus on the differences in EEG responses or brain computer interface (BCI) performance among different age groups. Current study illustrated the differences in the transient response and steady state response to the motion checkerboard paradigm in younger group (age ranges from 22 to 30) and senior group (age ranges from 60 to 75) for the first time. Three algorithms were utilized to test the performance of the four-targets steady state motion visual evoked potential (SSMVEP) based BCI. Results showed that the SSMVEP could be clearly elicited in both groups. And two strong transient motion related components i.e., P1 and N2 were found in the temporal waveform. The latency of P1 in senior group was significant longer than that in younger group. And the amplitudes of P1 and N2 in senior group were significantly higher than that in younger group. For the performance of identifying SSMVEP, the accuracies in senior group were lower than that in younger group in all three data lengths. And extended canonical correlation analysis (extended CCA)-based method achieved the highest accuracy (86.39% ± 16.37% in senior subjects and 93.96% ± 5.68% in younger subjects) compared with CCA-based method and task-related component analysis-based method in both groups. These findings may be helpful for researchers designing algorithms to achieve high classification performance especially for senior subjects.

Clinical characteristics of central serous chorioretinopathy in patients by age.

This study examines romantic and instrumental partner preferences in contact adverts from two Dutch newspapers, the Arnhemsche Courant (N = 283) and the Provinciale Drentsche en Asser Courant (N = 231) between 1900 and 1955. With the spread of the newspaper, contact adverts became a new meeting place. By means of short messages, people could make known that they were looking for a partner to get acquainted or even to marry and describe how their desired person should look like. By analysing how advertisers described themselves and their sought-after partners, insights into the motivations behind partner choice were gained. We identified a number of terms in the ads that could indicate romantic partner preferences, such as age homogamy, openness to regional or social heterogamy, and preferences indicating attraction, personality, and appearance. Similarly, instrumental partner preferences could be gathered from phrases expressing social homogamy (marrying into one’s own social class), parental influences, and the importance of wealth or possessions. The results show that romantic and instrumental considerations in partner preferences co-existed, but that their relative occurrence changed over time. Moreover, differential considerations in partner preference existed according to region, urban or rural residence, social class, religion, and gender. For instance, women’s partner preferences were more instrumental than those of men, while urban women were more likely to place contact adverts than rural women. Widows, widowers, and the divorced more often expressed romantic rather than instrumental partner preferences compared to unmarried men and women.

The aim of this study was to evaluate the impact of age on weight loss and on related glycolipid profile changes at 2-year follow-up after laparoscopic sleeve gastrectomy (LSG). From 2005 to 2010, a total of 308 consecutive patients undergoing LSG were enrolled. Mean age was 39.7 ± 10.7 years, mean weight was 127.9 ± 24.5 kg, and mean body mass index (BMI) was 45.9 ± 6.8 kg/m(2). Patients were divided into three age groups: young (18-29 years, n = 64), intermediate (30-49 years, n = 183), and senior (50-68 years, n = 61). BMI, excess weight loss (%EWL), and several biochemical examinations for the evaluation of glycolipid profile transition, including homeostasis model assessment for insulin resistance (HOMA-IR), were assessed at 6, 12, and 24 months (M6, M12, and M24) after LSG. All three groups had a significant BMI reduction and %EWL at 2 years' follow-up. The young group obtained significantly better %EWL at M6, M12, and M24 (62.6 ± 14.4, 73.4 ± 17.1, and 72.5 ± 18.9 %) compared to intermediate (53.2 ± 18.0, 64.8 ± 19.9, and 66.8 ± 23.0 %) and senior group (48.0 ± 15.5, 54.6 ± 15.3, and 54.4 ± 15.4 %). Fasting serum glucose levels improved significantly in all three groups at all follow-up assessment points (M6, M12, and M24). A significant improvement in HbA1c was also observed in the three groups at M6 and M12, while at M24 only patients in the young and intermediate groups still presented a significantly improved glycemic control. A significantly lower HOMA-IR improvement was observed at M6 in the senior group (2.83 ± 1.86) compared to both young (1.30 ± 0.54) and intermediate (1.43 ± 0.82) groups of patients. Total and low-density lipoprotein cholesterol level was significantly improved only in the young group. An age-dependent trend toward better %EWL and glycolipid profile improvement was observed in young patients after LSG.

Clinical Characteristics and Long-Term Prognosis of Senior Patients With BrugadaSyndrome.

ObjectiveBrain-computer interface (BCI) has great potential in geriatric applications. However, most BCI studies in the literature used data from young population, and dedicated studies investigating the feasibility of BCIs among senior population are scarce. The current study, we analyzed the age-related differences in the transient electroencephalogram (EEG) response used in visual BCIs, i.e., visual evoked potential (VEP)/motion onset VEP (mVEP), and steady state-response, SSVEP/SSMVEP, between the younger group (age ranges from 22 to 30) and senior group (age ranges from 60 to 75).MethodsThe visual stimulations, including flicker, checkerboard, and action observation (AO), were designed with a periodic frequency. Videos of several hand movement, including grasping, dorsiflexion, the thumb opposition, and pinch were utilized to generate the AO stimuli. Eighteen senior and eighteen younger participants were enrolled in the experiments. Spectral-temporal characteristics of induced EEG were compared. Three EEG algorithms, canonical correlation analysis (CCA), task-related component analysis (TRCA), and extended CCA, were utilized to test the performance of the respective BCI systems.ResultsIn the transient response analysis, the motion checkerboard and AO stimuli were able to elicit prominent mVEP with a specific P1 peak and N2 valley, and the amplitudes of P1 elicited in the senior group were significantly higher than those in the younger group. In the steady-state analysis, SSVEP/SSMVEP could be clearly elicited in both groups. The CCA accuracies of SSVEPs/SSMVEPs in the senior group were slightly lower than those in the younger group in most cases. With extended CCA, the performance of both groups improved significantly. However, for AO targets, the improvement of the senior group (from 63.1 to 71.9%) was lower than that of the younger group (from 63.6 to 83.6%).ConclusionCompared with younger subjects, the amplitudes of P1 elicited by motion onset is significantly higher in the senior group, which might be a potential advantage for seniors if mVEP-based BCIs is used. This study also shows for the first time that AO-based BCI is feasible for the senior population. However, new algorithms for senior subjects, especially in identifying AO targets, are needed.

The limited influence of self-monitoring on romantic partner preferences

Introduction Specific management of people with spinal cord injury has allowed to improve their life expectancy. The objective of this study was to analyze if age was a factor affecting the healing time of surgery for pelvic pressure ulcers in patients with spinal cord injury. Methods Retrospective, monocentric study, enrolling all consecutive spinal cord injury participants admitted into a specialized Neurological Physical Medicine and Rehabilitation department for surgery for pelvic pressure ulcers during a 5-year period. Participants were divided into two groups, “Young group” patients aged between 18 and 64 years and “Senior group” patients over 65 years of age. Healing time was defined as the time required for complete closure, allowing mobilization of the lower limbs. Data related to the complication rate (dehiscence, hematoma, infection, flap necrosis), medical or psychiatric decompensation, length of stay and time to rehabilitation were collected. Results One hundred and fourteen participants were recruited, including 77 participants in the “Young group” and 37 in the “Senior group”. In total, 131 pressure ulcers were operated. The median of the healing time was 46 [32.0;68.8] days, with a minimum of 20 days and a maximum of 694 days. Seven participants were considered as healing failures. There was no significant statistical difference between the two groups with 43 days [35.0;52.0] for the “Young group” and 56 days [40.0;80.0] for the “Senior group” (p = 0.44). Discussion This study demonstrated no significant difference in postoperative healing time of flaps for pelvic pressure ulcers between participant below and above 65 years of age.

To investigate the potential risk factors of organ dysfunction and mortality in the early resuscitation of severe sepsis and septic shock patients. Data were retrospectively analyzed from patients with severe sepsis and septic shock receiving non-cardiac operation and admitted to Department of Critical Care Medicine of the Second Affiliated Hospital of Kunming Medical University from January 1st,2013 to December 31st,2015.The patients were divided into the senior group (≥ 65 years old) and the younger group (＜ 65 years old),the high-procalcitonin (PCT) group (PCT ＞ 100 μg/L) and the control group (PCT ≤ 100 μg/L).The stage of early resuscitation was set to the first 6 hours. The diagnostic time and the incidence of acute respiratory distress syndrome (ARDS),acute kidney injury (AKI),and cardiac insufficiency were observed, which also included the usage of continuous renal replacement therapy (CRRT).The total fluid volume and the time of vasopressor usage during the first 6 hours of early goal-directed therapy (EGDT) were also recorded, which aslo included the 28-day mortality. 512 patients with severe sepsis and septic shock receiving non-cardiac operation were treated according to the guidelines of "Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock:2012".EGDT was used during the early resuscitation. The incidence of ARDS, AKI, and cardiac insufficiency was 80.9％ (414/512),71.3％ (365/512),and 61.9％ (317/512) respectively. There were 205 senior patients and 307 younger, as well as 154in high-PCT group and 358 in control group. The 28-day mortality was 30.3％ (155 died).90.8％ of patients (376/414)combined with ARDS were diagnosed before EGDT.95.1％ of patients (347/365) combined with AKI were diagnosed before EGDT, among whom 14.0％ (51/365) were treated with CRRT.153 senior patients combined with cardiac insufficiency were diagnosed no longer than 12 hours after EGDT. Compared with the younger group, the incidences of ARDS and cardiac insufficiency were higher in the senior group [85.9％ (176/205) vs.77.5％ (238/307),82.9％(170/205) vs.32.9％ (147/307),both P ＜ 0.05],so were the time of vasopressor usage during EGDT (hours:5.81 ±0.28vs.5.68 ± 0.52,P ＜ 0.05) was prolonged markedly and the 28-day mortality [42.9％ (88/205) vs.21.8％ (67/307),P ＜0.05] was increased significantly. But the incidence of AKI and the total fluid volume during EGDT were not significantly different between the senior group and the younger group [incidence of AKI:74.1％ (152/205) vs.69.4％ (213/307),total fluid volume (mL):2 769 ± 1 589 vs.2 804± 1 611,both P ＞ 0.05].Compared with the control group, the incidence of ARDS was higher in the high-PCT group [86.4％ (133/154) vs.78.5％ (281/358),P ＜ 0.05].But the incidences of AKI and cardiac insufficiency were not significantly differentiated between the high-PCT group and the control group [77.9％ (120/154) vs.68.4％ (245/358),58.4％ (90/154) vs.63.4％ (227/358),both P ＞ 0.05].Multiple logistic regression analysis showed that the risk factors of increase in mortality in patients with severe sepsis and septic shock included old age [odds ratio (OR) =1.782,95％ confidence interval (95％CI) =1.173-2.708,P =0.007],ARDS (OR =1.786,95％CI =1.028-3.102,P =0.040),AKI (OR =1.878,95％CI =1.145-3.079,P =0.012),and cardiac insufficiency (OR =4.177,95％CI =2.505-6.966,P =0.000),except for gender (OR =1.112,95％CI =0.736-1.680,P =0.614). In the senior postoperative patients with severe sepsis or septic shock, the incidence of ARDS and cardiac insufficiency, and the mortality were increased. The incidence of ARDS was correlated to the severity of infection.Old age, surgery, and EGDT could be the potential risk factors of cardiac insufficiency.

BackgroundEwing sarcoma (EwS) is a highly malignant and heterogeneous tumor. Exploring clinicopathological characteristics and genetic features of EwS is critical for prognosis and treatment regimen.MethodsClinicopathological characteristics and genetic features of young (≤ 30y) and senior (> 30y) EwS patients were analyzed based on histology, phenotype, and next-generation sequencing (NGS) detection.ResultsThe young group (18/36) presented nontypical EwS histological morphology, whereas the senior group (18/36) presented typical morphology. The prognosis of the young group was found to be worse compared with the senior group for patients without metastasis at the initial diagnosis. DNA- and RNA-based NGS was conducted on 20 extraosseous EwS patients. 16/20 samples demonstrated EWSR1-FLI1 fusion and 4/20 demonstrated EWSR1-ERG fusion. However, 13/16 EWSR1-FLI1fusions were detected both in DNA- and RNA-based NGS, 1/16 was detected only at the DNA level, and 2/16 were detected only at the RNA level. An analysis of the genetic profiles of the EWSR1-FLI1 cases revealed that the young group was inclined to couple with more copy number variations (CNV), such as CCND1, CDK4 amplification, and fusion variations, such as CHEK1-EWSR1, SLIT2-EWSR1, and EWSR1-FAM76B fusion. The senior group was more likely to have SNV or Indel mutations, such as EPHA3 and STAG2 mutations. Moreover, patients with more CNV abnormalities had a worse prognosis than those with predominantly SNP variants. In addition, compared with the senior group, the young group had significantly higher CyclinD1 protein expression.ConclusionClinicopathological characteristics and genetic features in young and senior EwS patients differed significantly. Targeting cell cycle dysregulation based on age subgroup may be a potential therapeutic strategy for Ewing sarcoma.

Background:Japan has a large number of senior citizens. Yoga can be wisely applied in old age care. There is no any age restriction to practice yoga. The effect may differ by age. There is a need to study the mechanism of action of yoga with respect to age.Aim:This study was conducted in Japan to find the effect of yoga on mental health between young and senior people.Materials and Methods:Twenty-five normal healthy volunteers of both sexes were divided into two groups according to age. Fifteen participants of the age group between 65 to 75 years and 10 participants of the age group between 20 to 30 years were selected. This study was approved by the ethical committee of Kawasaki University of Medical Welfare. Selected individuals were subjected to 90 min of yoga classes once or twice a week for a month. Salivary amylase activity was assessed before and after yoga practice. State Trait Anxiety Inventory (STAI) was given before yoga on the first day and after one month of practice to assess the change in State anxiety and Trait anxiety.ResultsSenior group – Salivary amylase activity decreased from 111.2±42.7 to 83.48±39.5 kU/L [average±standard deviation]. Younger group – Salivary amylase activity reduced from 60.74±31.8 to 42.39±24 kU/L. Senior group – State anxiety score decreased from 41.13 ±8.43 to 30.8±6.49, Trait anxiety score reduced from 45.66±7.5 to 40.73±8.3. Younger group – State anxiety score reduced from 38.7±4.8 to 30.8±4.1,Trait anxiety score reduced from 46.2±7.9 to 42.9±9.1. Changes were statistically significant with P<0.05.Conclusion:Decrease in Salivary amylase activity may be due to reduction in sympathetic response. Reduction in State and Trait anxiety score signifies that yoga has both immediate as well as long-term effect on anxiety reduction. Thus yoga helps to improve the mental health in both the groups.

Socioeconomic inequalities in healthcare services are major public health and healthcare concerns. We have examined the association of income with symptoms, morbidities and healthcare usage in a national sample of the Japanese population. For this study, data compiled on 21,929 men and 24,620 women from the Comprehensive Survey of the Living Conditions of People on Health and Welfare in 2007 were assessed. Among the survey respondents with symptoms, we compared the prevalences of symptoms and treatments and the number of respondents who received treatments for 16 groups of symptoms and disorders according to household income, from the highest to the lowest, using the relative index of inequalities (RII). The RIIs were computed by age groups [25-59years (young group) and 60+ years (senior group)]. People with lower incomes had higher prevalences of symptoms and treatments for most of the disorders examined. The RIIs of symptoms and treatments were 1.19 [95% confidence interval (CI) 1.09-1.31] and 1.04 (95% CI 0.93-1.16) for the young group and 1.69 (1.53-1.87) and 1.51 (1.36-1.67) for the senior group, respectively. In terms of treatment prevalence among those with symptoms, the RII was not significantly lower than 1.0 except for a few disorders in the young group. Our results indicate that income inequalities can be related to the prevalences of various symptoms and morbidities in our Japanese sample population and that these inequalities were greater in the senior group than in the young group. Our results also suggest that lower income is not a substantial barrier to the use of healthcare services by older Japanese individuals, while it is related to lower healthcare usage by individuals of working age.