Abstract
Behçet disease is a multisystem vasculitis with unknown etiology. Ocular involvement, especially posterior segment involvement is the most devastating manifestation of the disease and is an absolute indication for immunosuppressive treatment. However, immunosuppression with conventional agents may be inadequate to prevent destructive uveitis attacks and consequently visual loss. Interferons that constitute the next step of the treatment are the cytokines, which have antiviral, antiproliferative, and immunomodulatory features. They are quite effective in the treatment of Behçet uveitis. They prevent recurrent attacks and improve visual prognosis. They are used successfully in the treatment of macular edema and retinal neovascularizations. Furthermore, they provide long-term remission after the secession of interferon treatment. The aim of this review is to summarize the mechanism of action and the effectiveness and safety of interferons in the treatment of Behçet uveitis.
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