Abstract
Obstructive voiding disorder (OVD) occurs during aging in men and is often, but not always, associated with increased prostate size, due to benign prostatic hyperplasia (BPH), prostatitis, or prostate cancer. Estrogens are known to impact the development of both OVD and prostate diseases, either during early urogenital tract development in fetal–neonatal life or later in adulthood. To examine the potential interaction between developmental and adult estrogen exposure on the adult urogenital tract, male CD-1 mice were perinatally exposed to bisphenol A (BPA), diethylstilbestrol (DES) as a positive control, or vehicle negative control, and in adulthood were treated for 4 months with Silastic capsules containing testosterone and estradiol (T+E2) or empty capsules. Animals exposed to BPA or DES during perinatal development were more likely than negative controls to have urine flow/kidney problems and enlarged bladders, as well as enlarged prostates. OVD in adult T+E2-treated perinatal BPA and DES animals was associated with dorsal prostate hyperplasia and prostatitis. The results demonstrate a relationship between elevated exogenous estrogen levels during urogenital system development and elevated estradiol in adulthood and OVD in male mice. These findings support the two-hit hypothesis for the development of OVD and prostate diseases.
Highlights
Obstructive voiding disorder (OVD) is common in aging men, and it is characterized by urgency, increased frequency of urination, hesitancy, low urine flow pressure, and incomplete bladder emptying, which can lead to acute kidney injury
OVD is associated with increased prostate size due to benign prostatic hyperplasia (BPH) or chronic prostatitis in approximately two-thirds of male cases, but OVD can occur in the absence of any evidence of prostate enlargement [1]
The other subset of perinatal control animals and animals perinatally treated with bisphenol A (BPA) or DES were implanted in adulthood with two Silastic capsules, one containing testosterone (T) and the other containing estradiol (E2); these groups are referred to as CTL-TE2, BPA-TE2, and DES-TE2 groups, respectively
Summary
Obstructive voiding disorder (OVD) is common in aging men, and it is characterized by urgency, increased frequency of urination, hesitancy, low urine flow pressure, and incomplete bladder emptying, which can lead to acute kidney injury. We have found that exposure during the fetal period of urogenital sinus (UGS) differentiation to estradiol, as well as the estrogenic drugs diethylstilbestrol (DES) and ethinylestradiol (EE2), and to bisphenol A (BPA), an endocrine-disrupting chemical that has estrogenic activity and is used in many products, causes a decrease in diameter of the urethra and constriction of the bladder neck. All of these estrogenic compounds cause other gross UGS malformations, in the colliculus region of the dorsal prostate in male mouse and rat fetuses [4,5,6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
