Abstract
The interactions of Co-enzyme Q0 with Aniline and Pyrrole were studied in aqueous phosphate buffer solution at (pH=7.0) as supporting electrolyte using square wave voltammetry, Co-enzyme Q0 gives a well-defined square wave voltammetric peak at (-0.0415) volt against the reference electrode (Ag/AgCl/3M KCl). The binding constants (K) were calculated at different temperatures. Vant's hoff equation is applied to calculate the thermodynamic parametrs (ΔH enthalpy changes, ΔS entropy changes and ΔG free energy changes), and then the type of interaction was estimated. The results indicated that the interaction between Co-enzyme –Q0 and Aniline (ΔH and ΔS negative values) was probably due to Vander Waals forces or hydrogen bonding interaction, and the second interaction between Co-enzyme-Q0 with Pyrrole (ΔH and ΔS positive values) might be due to the hydrophobic interaction .
Highlights
The chemical structure of coenzyme Q0 (CoQ0) is C10H12O4, 2,3-dimethoxy-5-methyl -1,4benzoquinone, (Al-Nuri et al.,2011)
UQ is believed to be critically involved in mitochondrial reactive oxygen species (ROS) generation, like semi ubiquinone generated during electrons transport which can react with oxygen molecule to form the superoxide anion
The square wave voltammogram was recorded for co-enzyme-Q0 under the measured optimum conditions (Table 1).The appropriate amount of (1.1x10-4M) of aniline was added to the cell and the square wave voltammogram was recorded at different temperatures in the range (289-308)0K in order to calculate the thermodynamic parameters ∆H, ∆S and ∆G
Summary
The chemical structure of coenzyme Q0 (CoQ0) is C10H12O4, 2,3-dimethoxy-5-methyl -1,4benzoquinone, (Al-Nuri et al.,2011). (1) Coenzyme Q (CoQ) known as Ubiquinone (UQ), is a redox-active lipophilic molecule that is found in all cells and in the membranes of many organelles where it participates in a variety of cellular processes (Turunen et al, 2004). The square wave voltammogram was recorded for co-enzyme-Q0 under the measured optimum conditions (Table 1).The appropriate amount of (1.1x10-4M) of aniline was added to the cell and the square wave voltammogram was recorded at different temperatures in the range (289-308)0K in order to calculate the thermodynamic parameters ∆H, ∆S and ∆G.
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