Abstract
Understanding the interaction between drug-metal complexes is important to find out the pharmacological characteristics of a drug. In this work, one of the μ-opioid analgesic type of drug, tapentadol has been used to study the interaction of tapentadol with several metal ions such as Ca (II), K (I) Cr (III), Cu (II), Fe (III), Co (II), and Ni (II) using UV-Vis and FTIR spectroscopy. It was found that tapentadol forms drug-metal complexes with transition metals like Fe (III) and Ni (II) only in acidic conditions. Whereas Cu (II) can interact with tapentadol both in acidic and basic conditions. This study may help to understand the interactions of μ-opioid drugs with the metal ions which ultimately help to develop new drugs of this class with more efficacy.
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