Abstract
In order to examine the application of tablets of polyelectrolytes, crosslinked with divinylbenzene to a low degree, to disintegration agent, two kinds of materials with different degree of swelling, crosslinked polyacrylic acid and crosslinked polymethacrylic acid, were selected and their disintegration behavior was examined from the point of swelling and fluidity, in the disintegration of valnoctamide tablet, which is extremely difficult to disintegrate, in water, and in the presence of inorganic salts or dl-methylephedrine hydrochloride. Valnoctamide tablet added with crosslinked polyelectrolyte underwent more rapid disintegration than the control tablet, and the logarithm of disintegration time approximately decreased with increasing velocity of swelling in water. In the system with small degree of swelling, such as in the presence of a neutral salt, disintegration was found to be dependent on the product of swelling velocity and degree of equilibrium swelling was also found that such tablets underwent disintegration by the liberation of the constituent component particles from the surface of swollen tablets by a relatively small shearing force.
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Schedule a callMore From: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
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