Abstract
Mitotic kinesin Eg5 remains a validated target in the antimitotic therapy due to its essential role in the maintenance of mitotic spindles bipolarity. Although numerous inhibitors of Eg5 from synthetic origin are known, only few inhibitors from natural products have been reported. In our current study, we focused on identifying novel Eg5 inhibitors from medicinal plants, particularly Garcinia spp. We herein report the discovery of a biflavonoid, kolafavanone, which inhibited both the basal and microtubule-stimulated ATPase activities of mitotic kinesin Eg5 in vitro.
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