Abstract
India has one of the highest incidences of oral cancer (OC) in the world. OC susceptibility is related to the polymorphism of drug-metabolising genes because they are responsible for metabolising chemical carcinogens, which are present in tobacco and alcohol. The aim of this study was to determine the potential role of drug-metabolising CYP1A1 and GSTM1 gene polymorphisms and the risk of OC in Chhattisgarh. For the assessment of association between the polymorphism of CYP1A1 and GSTM1 genes and risk of tobacco-related OC in Chhattisgarh population, we examined the prevalence of CYP1A1 and GSTM1 null polymorphisms using PCR- and restriction fragment-length polymorphism-based methods in seventy-four histologically confirmed OC patients and in seventy-four age- and sex-matched healthy controls. Demographic information and biological samples were collected by individual-informed written consent of subjects. To know the potential gene–environment interaction, analyses were conducted by stratifying the tobacco (smoking, chewing) and alcohol consumption status and odds ratio (OR) estimation was conducted using SPSS (version 16.0) software. The increased risk for OC was observed among subjects with homozygous CYP1A1 (m2/m2) genotype (OR = 1.39; 95% CI = 0.68–2.84) and GSTM1 null genotype (OR = 1.31; 95% CI = 0.69–2.50). Furthermore, the risk for OC significantly increased in subjects with the homozygous CYP1A1 (m2/m2) genotype with tobacco-chewing and alcohol-drinking history (chewer; OR = 2.08; 95% CI = 0.84–5.20; alcohol drinker; OR = 2.07; 95% CI = 0.69–6.21). The combination of CYP1A1 (m2/m2) and GSTM1 null genotypes is a significant risk for OC (OR = 2.38; 95% CI = 0.678.49, p= 0.031). Our findings indicate that the combined net effect of null mutation on CYP1A1 and GSTM1 genes along with tobacco and alcohol habit increased 2.5-fold risk of OC in Chhattisgarh population.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
