Integrating machine learning and finite element simulation for interpretable prediction of 3D-printed bone scaffold mechanics

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An integrated framework combining Finite Element Analysis (FEA) and Artificial Neural Networks (ANN) is presented to enhance the prediction and design of bioprinted scaffolds. By leveraging the strengths of data-driven learning and physics-based simulations, the hybrid approach (ANN + FEA) achieves superior predictive accuracy and generalization compared to standalone approaches. Validation against experimental results demonstrates that a single ANN model yields a relative error of 5.17% when predicting scaffold Young’s modulus. Incorporating FEA simulation based on ANN-predicted geometry and material properties reduces the relative error to 4.72%, representing an 8.6% improvement. The framework also enables the accurate simulation for unseen combinations of printing parameters located far from the experimental data manifold, reducing prediction errors from 14.2% (ANN-only) to 5.7% (hybrid). By integrating predictive modeling, simulation, and data augmentation, this approach offers an efficient pathway for optimizing scaffold designs and accelerating the development of biomaterials with tailored mechanical performance.

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Empirical modeling of stress concentration factors using artificial neural networks for fatigue design of tubular T-joint under in-plane and out-of-Plane bending moments
  • Jun 14, 2024
  • International Journal of Structural Integrity
  • Adnan Rasul + 5 more

PurposeStress concentration factors (SCFs) are commonly used to assess the fatigue life of tubular T-joints in offshore structures. SCFs are usually estimated from parametric equations derived from experimental data and finite element analysis (FEA). However, these equations provide the SCF at the crown and saddle points of tubular T-joints only, while peak SCF might occur anywhere along the brace. Using the SCF at the crown and saddle can lead to inaccurate hotspot stress and fatigue life estimates. There are no equations available for calculating the SCF along the T-joint's brace axis under in-plane and out-of-plane bending moments.Design/methodology/approachIn this work, parametric equations for estimating SCFs are developed based on the training weights and biases of an artificial neural network (ANN), as ANNs are capable of representing complex correlations. 1,250 finite element simulations for tubular T-joints with varying dimensions subjected to in-plane bending moments and out-of-plane bending moments were conducted to obtain the corresponding SCFs for training the ANN.FindingsThe ANN was subsequently used to obtain equations to calculate the SCFs based on dimensionless parameters (α, β, γ and τ). The equations can predict the SCF around the T-joint's brace axis with an error of less than 8% and a root mean square error (RMSE) of less than 0.05.Originality/valueAccurate SCF estimation for determining the fatigue life of offshore structures reduces the risks associated with fatigue failure while ensuring their durability and dependability. The current study provides a systematic approach for calculating the stress distribution at the weld toe and SCF in T-joints using FEA and ANN, as ANNs are better at approximating complex phenomena than typical data fitting techniques. Having a database of parametric equations enables fast estimation of SCFs, as opposed to costly testing and time-consuming FEA.

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