Abstract
The association between chronic inflammatory diseases, such as rheumatoid arthritis and psoriasis, and insulin resistance (IR) has been well established. Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease that affects the apocrine gland-bearing areas of the body. We aimed to determine the prevalence of IR in patients with HS. This cross-sectional, case-control study enrolled 137 subjects, 76 patients with HS and 61 age- and gender-matched controls. Demographic data, clinical examination of HS patients, anthropometric measures, cardiovascular risk factors and laboratory studies were recorded. The homeostasis model assessment of IR (HOMA-IR) was calculated in all participants by measuring fasting plasma glucose and insulin levels. The median (IQR) HOMA-IR value in HS patients was significantly higher [2.0 (1.0-3.6)] than in controls [1.5 (0.9-2.3)] (P = 0.01). The prevalence of IR was significantly higher in cases (43.4%) compared with controls (16.4%) (P = 0.001). In the linear regression multivariable analysis after adjusting for age, sex and body mass index (BMI), HS remained as a significant factor for a higher HOMA-IR [2.51 (0.18) vs 1.92(0.21); P = 0.04]. The HOMA-IR value and the prevalence of IR did not differ significantly among HS patients grouped by severity of the disease. Our results show an increased frequency of IR in HS. Thus, we suggest HS patients to be evaluated for IR and managed accordingly.
Highlights
Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease of the hair follicle characterized by relapsing painful inflammatory nodules, abscesses and fistula tracts in the apocrine gland-bearing areas of the body, most commonly in the axillae, inguinal and anogenital regions.[1,2,3] HS incidence ranges between 4 and 10 cases per 100 000 population/year and prevalence between 0,2% and 4%.3 its pathogenesis is not completely understood, it is postulated to begin with disturbed keratinization of the follicular infundibulum which results in follicular occlusion.[4]
It should be noted that the premature and accelerated development of atherosclerosis in patients with HS is independent of these CV risk factors.[14,15]. This fact suggest that HS itself may be an independent risk factor for atherosclerotic CV disease, and that other disease-related factors may be implicated in the premature development of the atherogenic process in HS patients
In accordance with other previous reports,[27,28,29] we found in our series of HS patients a significantly higher prevalence of metabolic syndrome (MS) than in the control group
Summary
Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease of the hair follicle characterized by relapsing painful inflammatory nodules, abscesses and fistula tracts in the apocrine gland-bearing areas of the body, most commonly in the axillae, inguinal and anogenital regions.[1,2,3] HS incidence ranges between 4 and 10 cases per 100 000 population/year and prevalence between 0,2% and 4%.3 its pathogenesis is not completely understood, it is postulated to begin with disturbed keratinization of the follicular infundibulum which results in follicular occlusion.[4]. Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease of the hair follicle characterized by relapsing painful inflammatory nodules, abscesses and fistula tracts in the apocrine gland-bearing areas of the body, most commonly in the axillae, inguinal and anogenital regions.[1,2,3] HS incidence ranges between 4 and 10 cases per 100 000 population/year and prevalence between 0,2% and 4%.3. Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease that affects the apocrine glandbearing areas of the body. Results: The median (IQR) HOMA-IR value in HS patients was significantly higher [2.0 (1.0-3.6)] than in controls [1.5(0.9-2.3)] (p=0.01). The prevalence of IR was significantly higher in cases (43.4%) compared with controls (16.4%) (p=0.001). The HOMA-IR value and the prevalence of IR did not differ significantly among HS patients grouped by severity of the disease. We suggest HS patients to be evaluated for IR and managed
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