Abstract
BackgroundInsulin resistance is the primary metabolic disorder associated with obesity; yet little is known about its role as a determinant of the metabolic syndrome in obese children. The aim of this study is to assess the association between the degree of insulin resistance and the different components of the metabolic syndrome among obese children and adolescents.MethodsAn analytical, cross-sectional and population-based study was performed in forty-four public primary schools in Campeche City, Mexico. A total of 466 obese children and adolescents between 11-13 years of age were recruited. Fasting glucose and insulin concentrations, high density lipoprotein cholesterol, triglycerides, waist circumference, systolic and diastolic blood pressures were measured; insulin resistance and metabolic syndrome were also evaluated.ResultsOut of the total population studied, 69% presented low values of high density lipoprotein cholesterol, 49% suffered from abdominal obesity, 29% had hypertriglyceridemia, 8% presented high systolic and 13% high diastolic blood pressure, 4% showed impaired fasting glucose, 51% presented insulin resistance and 20% metabolic syndrome. In spite of being obese, 13% of the investigated population did not present any metabolic disorder. For each one of the components of the metabolic syndrome, when insulin resistance increased so did odds ratios as cardiometabolic risk factors.ConclusionsRegardless of age and gender an increased degree of insulin resistance is associated with a higher prevalence of disorders in each of the components of the metabolic syndrome and with a heightened risk of suffering metabolic syndrome among obese children and adolescents.
Highlights
Insulin resistance is the primary metabolic disorder associated with obesity; yet little is known about its role as a determinant of the metabolic syndrome in obese children
It is worth noting that no consensus exists concerning the HOMA-Insulin resistance (IR) cut-off points that define IR among the pediatric population, there is general agreement that IR is a common pathway for the development of glucose metabolism disorders, dyslipidemias, and high blood pressure, all of which are components of the metabolic syndrome (MS) [7,8,9]
This study aims to elucidate the prevalence of IR and to evaluate the association of IR with each of the components of MS among obese children and adolescents
Summary
Insulin resistance is the primary metabolic disorder associated with obesity; yet little is known about its role as a determinant of the metabolic syndrome in obese children. The aim of this study is to assess the association between the degree of insulin resistance and the different components of the metabolic syndrome among obese children and adolescents. It is worth noting that no consensus exists concerning the HOMA-IR cut-off points that define IR among the pediatric population, there is general agreement that IR is a common pathway for the development of glucose metabolism disorders, dyslipidemias, and high blood pressure, all of which are components of the metabolic syndrome (MS) [7,8,9]. MS is a risk factor for the subsequent development of type-2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) [10]
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