Insulin-like growth factor-binding protein 7 (IGFBP7): Novel, independent marker of cardiometabolic diseases?

Abstract

Insulin-like growth factor-binding protein 7 (IGFBP7) is a 30kDa modular secreted protein involved in many physiologic processes, including cell proliferation, adhesion, senescence and angiogenesis. It is expressed in many organs and specific cells. It can interact with insulin-like growth factor 1(IGF-1), as well as with insulin. By binding to IGF-1, it limits IGF-1 access to IGF- receptor (IGF-R) and consequently neutralizes IGF-1 activity. Moreover, due to its high affinity to insulin, it may interfere with biological response of insulin and, therefore, it may be involved in the development of diabetes and cardiovascular diseases. According to research, it could be a good biomarker of heart failure. Its elevated serum concentrations were found in patients with heart failure, both with reduced ejection fraction and preserved ejection fraction. Moreover, IGFBP7 could be useful in predicting the presence of atherosclerotic lesions in coronary vessels, although its concentration does not reflect a degree of coronary artery disease (CAD) advancement and it cannot be used as a marker of acute ischemia. Its concentration is also associated with insulin resistance and the risk of metabolic syndrome. What is more, together with tissue inhibitor of metalloproteinases-2, it is a novel marker of tubular damage and it can be used for an early detection of acute kidney injury (AKI) endangered patients, which could allow for subsequent adjustments in medical therapy and the prevention of AKI. IGFBP7 is also regarded as a potential tumor suppressor in various cancers. Its low expression is potentially correlated with increased cancer cell proliferation.