Abstract
Simple SummaryThe height, length and body-weight are the economic traits of Jindo dogs and it is necessary to study their underlying genetic basis. Thus, a post-genome-wide association enrichment study on four body-size traits of Jindo dog including height, length, length to height ratio and body-weight was carried out here. The results revealed several potential single nucleotide polymorphisms (SNPs) and genes which were significantly associated with the traits of interest. Furthermore, we have found several pathways to be significantly associated with the traits of interest and these pathways are generally involved in the growth and development process. The findings of this study may help to use the identified SNPs and genes as possible biomarkers for Jindo breeding.As a companion and hunting dog, height, length, length to height ratio (LHR) and body-weight are the vital economic traits for Jindo dog. Human selection and targeted breeding have produced an extraordinary diversity in these traits. Therefore, the identification of causative markers, genes and pathways that help us to understand the genetic basis of this variability is essential for their selection purposes. Here, we performed a genome-wide association study (GWAS) combined with enrichment analysis on 757 dogs using 118,879 SNPs. The genomic heritability (h2) was 0.33 for height and 0.28 for weight trait in Jindo. At p-value < 5 × 10−5, ten, six, thirteen and eleven SNPs on different chromosomes were significantly associated with height, length, LHR and body-weight traits, respectively. Based on our results, HHIP, LCORL and NCAPG for height, IGFI and FGFR3 for length, DLK1 and EFEMP1 for LHR and PTPN2, IGFI and RASAL2 for weight can be the potential candidate genes because of the significant SNPs located in their intronic or upstream regions. The gene-set enrichment analysis highlighted here nine and seven overlapping significant (p < 0.05) gene ontology (GO) terms and pathways among traits. Interestingly, the highlighted pathways were related to hormone synthesis, secretion and signalling were generally involved in the metabolism, growth and development process. Our data provide an insight into the significant genes and pathways if verified further, which will have a significant effect on the breeding of the Jindo dog’s population.
Highlights
The Jindo dog is a magnificent Korean indigenous breed that originated from the Jindo county of South Korea
We investigated 757 Jindo dogs with an average raw height of 48.51 cm, ranging from 33.5 to 59 cm and an average length of 51.42 cm ranging from 37 cm to 62 cm
We have discovered several new unreported as well as previously identified markers, genes and pathways that might influence the variation in height, length, length to height ratio (LHR) and body-weight of Jindo dog using genome-wide association study (GWAS) with pathway-based approaches
Summary
The Jindo dog is a magnificent Korean indigenous breed that originated from the Jindo county of South Korea. It has been highly regarded for its hostile disposition and watchfulness characteristics. Club and Federation [1] This breed has dark brown bright coloured eyes, small erected triangular ears and rolled up or sickle-shaped tails with acute hearing and sense of smell [2]. The majority of Jindo owners keep them for farmhouse income, as a watchdog and hunting. These days, the dogs are intensively farmed and kept as affectionate companion dog. The Jindo dog ranked 8th in the list of canine breeds kept as pets, falling behind other foreign breeds, and was found in only 4%
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