Abstract
Purpose: To assess the effectiveness of antidepressant medication adherence-improving intervention by a pharmacist and its impact on clinical symptoms of depression among outdoor depressive patients. Methods: Various databases such as PubMed, Embase, and Scopus were used sources for the literature published during the last 20 years. Pharmacist intervention studies involving adult depressed patients (≥ 17 years old) and treated with antidepressants were included. Twelve studies met the inclusion criteria. Results: These studies depicted various levels of interventions in which pharmacist counseled and educated the patients to support medication adherence. In only one of the studies, pharmacist intervention exercised significant effect on the depression features of patients. Conclusion: The findings suggest that the implication of antidepressant medication adherenceimproving intervention by pharmacist leads to the improved adherence of adult depressive patients to antidepressants. However, pharmacist intervention did not show any significant influence on depression symptomology, necessitating further studies on the topic. Keywords: Pharmacist care, Depression, Antidepressants, Intervention, Medication adherence
Highlights
Depression is one of the most prevalent mental health disorder worldwide [1,2,3] and will likely become the second largest reason for health illness globally by the year 2020 [4]
Depression can be effectively treated with antidepressants, patient nonadherence to medication is a substantial barrier to treatment success in clinical practice [7,8]
Factors related to the patient, clinical setting, social behavior, and medication affect are involved in patient adherence
Summary
Depression is one of the most prevalent mental health disorder worldwide [1,2,3] and will likely become the second largest reason for health illness globally by the year 2020 [4]. In the USA, several billions of cost is associated with depression disorders [5]. Antidepressant agents are primarily used to manage depression [6]. Depression can be effectively treated with antidepressants, patient nonadherence to medication is a substantial barrier to treatment success in clinical practice [7,8]. World Health Organization (WHO) has included depression to top 10 chronic disorders, which require medication adherence [9]. Some studies have revealed a significant positive effect of hospital admission on medication nonadherence [10]
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