Abstract
To determine whether the intracellular calcium-mobilizing second messenger, inositol 1,4,5-trisphosphate (InsP 3) and its receptor (InsP 3R) display age-dependent coordinate regulation, InsP 3 content and [ 3H]InsP 3-binding characteristics were investigated in cerebellar particulate membranes prepared from male Fischer 344 rats at 3, 12 and 25 months of age. Cerebellar InsP 3 content was significantly increased in 25-month-old rats compared with 3-month-old animals. Cerebellar InsP 3R densities were significantly reduced at 12 and 25 months of age but InsP 3-binding affinity was significantly decreased only in the 25-month-old animals. The present data strongly suggest that modulation of the phosphoinositide second messenger system may contribute to impaired neuronal responsiveness associated with the aging process in the cerebellum.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
