Abstract
A series of inorganic-biomolecular hybrids FAnPMo12−nVnO40 (n=1, 2, and 3, abbreviated as FAPMoVn, FA represents folic acid) had been synthesized through self-assembly of bioactive molecules folic acids and phosphovanadomolybdates. These folate-functionalized hybrids had been proved to possess unique oxidase-like activity in the oxidation of dyes, which can catalyze oxidation of the peroxidase substrate 3,3′,5,5′-tetramethylbenzidine (TMB) by air to form a blue color in aqueous solution. Among all hybrids, FAPMoV3 performed best. Based on their oxidase property, an approach instead of traditional horseradish peroxidase (HRP)-labeled assay for the visual detection of cancer tumors by FAPMoV3 had been built up. FAPMoV3 exhibited fast response and high efficiency in colorimetric immunoassay of cancer cells at a neutral pH condition.
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