Abstract
Background: Epidemiological evidence suggests an association between cardiovascular disease and environmental pollutants. Arsenic is a common contaminant in drinking water throughout the world, and recent studies suggest a link between inorganic arsenic (iAS) exposure and ischemic heart disease. Although female hearts exhibit an estrogen-dependent reduction in susceptibility to ischemic injury compared to males, females may be especially vulnerable to iAS exposure due to endocrine disrupting effects. However, iAS exposure and susceptibility to ischemic heart injury have not been examined in mechanistic studies.
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