Abstract
This paper is aimed to develop stabilizers with the conserving effect that helps to prolong the expiry date with the blood stabilization up to the relevant processing, including the fractionation characteristic selection. Theoretical and experimental studies are performed to comply with the tasks at hand at the “Bionanotechnology” Chair of the Kemerovo Institute of Food Science and Technology (University). The entire research cycle consisted of several correlated stages. The national and international literature available was analyzed to state objectives and tasks at the first stage. Whole blood stabilization parameters are selected with the concurrent conservation to improve the stability of erythrocyte membranes. The best value of the separation factor is selected wherein the application condition of high separation factor values is taken as the baseline for the blood fractionation. The process of citric acid influence is analyzed as the preservative agent on the blood viscosity, blood pH and total bacterial content. A calibration dependence graph of the separating unit rotation velocity (separator, centrifuge) is worked out of the unit rotation radius. The fractional composition of the derived protein components of red blood cells of the bovine cattle and porcine bloods is analyzed to prove the benefit of fractionation characteristics obtained. The following fractions are revealed in the packed red cells as follow: haptoglobin, fibrinogen, globulin, one of its three forms, hemoglobin, the protein of the platelet-leukocyte group.
Highlights
Iron-deficiency anemia is one of the most common human diseases
Of all patents relating to iron deficiency anemia management and prevention, only about onefourth are based on the use of heme iron
The molecular-mass distribution of proteins and peptides in the resulting hydrolyzates is evaluated by the electrophoretic method in the polyacrylamide gel (PAGE) by the Laemmli method
Summary
Iron-deficiency anemia is one of the most common human diseases. Pregnant and children aged up to 8 are most susceptible to this disease. To prevent the disease consequences, new therapeutic and preventive products should be investigated and developed to manage the iron deficiency anemia [1]. Alimentary albumin is used in many medical products to prevent the iron deficiency that is prepared from the whole blood of slaughter animals, rather than the specially isolated hemoglobin. 20% patents propose medications to manage the iron deficiency anemia, 80% patents offer products of therapeutic and preventive effect with the high content of iron in various forms [6]. Such products are saturated with vitamins and mineral nutrients. The research is aimed to develop stabilizers with the preservative effect that allow extending the shelf life during blood stabilization prior to appropriate processing, as well as the selection of the fractionation characteristics with primary isolation of the heme iron
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