Abstract
To assist or replace the traditional suture techniques for wound closure, soft-tissue adhesives with excellent adhesion strength and favorable biocompatibility are of great significance in biomedical applications. In this study, an injectable hydrogel tissue adhesive containing adipic acid dihydrazide–modified gelatin (Gel-ADH) and oxidized sodium alginate (OSA) was developed. It was found that this tissue adhesive possessed a uniform structure, appropriate swelling ratio, good injectability, and excellent hemocompatibility and cytocompatibility. The adhesion capacity of the developed adhesive with optimized component and concentration was stronger than that of the commercial adhesive Porcine Fibrin Sealant Kit. All these results suggested that the developed hydrogel was a promising candidate for a soft-tissue adhesive.
Highlights
Rapid hemostasis and effective wound closure are very important in wound repair
Compared with the spectra of sodium alginate (SA), a new absorption peak at 1726 cm−1 which is due to the aldehyde group was observed in oxidized sodium alginate (OSA)
The oxidation degree of OSA used in this study was about 79%
Summary
Rapid hemostasis and effective wound closure are very important in wound repair. Conventional suturing is usually time consuming and cannot close the wound immediately, which can lead to a variety of pathologic scenarios, such as tissue morbidities and mortalities (Geng et al, 2020; Zhu et al, 2020). In comparison with fibrin glue, cyanoacrylates have much stronger adhesion capacity, but the excessive heat and the cytotoxic byproducts produced in the fast polymerization process during bonding are a major concern (Lv et al, 2021). Their poor elasticity cannot accommodate the movement of soft tissues under a highly dynamic physiological environment (Li et al, 2020; Zhao et al, 2021). Development of ideal medical adhesives with good biocompatibility, sufficient mechanical property, tunable biodegradability, and rapid and strong adhesion has a great application value in wound closure and healing (Neuffer et al, 2004; Gillman et al, 2020)
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