Abstract
ABSTRACT In this work, novel injectable and radiopaque calcium phosphate bone cements were prepared using zirconia short fiber as a radiopacifier. The radiopacity, setting time, injectability, anti-washout ability, microstructure, mechanical property, and the in vitro cytocompatibility of the novel cements were evaluated thoroughly. The results reveal that the incorporation of zirconia fiber significantly improves the radiopacity of bone cement while it has no significant effect on the setting time, anti-washout ability, and injectability. The cements are still injectable and show good manual operability. Moreover, the flexural strength and compressive strength of the composite bone cement with 2 wt% fibers are enhanced. Additionally, MTT results reveal that the zirconia fiber doped cements exhibit no cytotoxicity toward osteoblastic MG63 cells, and MG63 cells can adhere and proliferate well on the cements. Therefore, calcium phosphate bone cement containing zirconia fibers has the potential to be used as a bone repair material for minimally invasive surgery.
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