Abstract
Tumor-associated macrophages (TAMs) are a significant component of the microenvironment of any solid tumors in the majority of cancers, associated with unfavorable prognosis. TAMs emerge as attractive targets for therapeutic strategies aimed at reprogramming their protumor phenotype into an effective antitumor activity.In this review article, we present an overview of mechanisms responsible for TAMs recruitment and highlight the roles of TAMs in the regulation of tumor angiogenesis, invasion, metastasis, immunosuppression, and chemotherapeutic resistance. We describe the interplay between Th17 cells and other immune cells in the tumor microenvironment, and we assess both the potential antitumorigenic and pro-tumorigenic activities of Th17 cells and their associated cytokines. Understanding the nature of Th17 cell responses in the tumor microenvironment will be important for the design of more efficacious cancer immunotherapies. Finally, we discuss TAM-targeting therapy as a promising novel strategy for an indirect cancer therapy.
Highlights
Cancer is a disease characterized by rapid growth of cells in the body, often in the form of a tumor
Stimulating the adaptive immune system which depends on major histocompatibility complex (MHC)restricted ab-T cells are major immunotherapeutic approaches for an anti-tumor response. gd T cells are considered to be a member of innate immune cells which shows an important role in immune defense and Immunosurveillance against tumors, such as leukemia, neuroblastomas, lymphomas, melanomas, and other types of carcinomas [29,31]
Granulocytes is a type of immune cell with the key mediators of inflammation having a potential role in the initiation of immune response and cascades against tumors [44]
Summary
Cancer is a disease characterized by rapid growth of cells in the body, often in the form of a tumor. This review will throw some lights on anti-cancer therapy and drugs delivery process by TAMs. This review will throw some lights on anti-cancer therapy and drugs delivery process by TAMs It is not the intent of this review to provide an in-depth description of each macrophage, types and classification of tumors and metastasis of various tumor as each topic itself can be a lengthy review. It hoped that this review can serve as a lead for readers who are interested in the recent development of the functions of TAMs during tumor metastasis
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