Abstract
Injection of CaATP solutions subcutaneously in rats resulted in the formation of white, circumscribed, gritty plaques containing amorphous calcium phosphate (Ca/P 1.3–1.5). Dense, rod-shaped deposits were oriented along the fibrous elements and surrounding blood vessels in the subcutaneous connective tissue. The response was dose related, the amount of plaque calcium being about 100 times the amount injected. These results suggest that the calcium phosphate formed from CaATP in the ATPase active subcutaneous tissue may nucleate crystallization. Injection of a solution of CaCl2 having the same concentration as the calcium in the CaATP solution, or of a sodium phosphate solution having the same concentration of phosphorus as the CaATP, did not produce plaques. However, injection of a solution containing both Ca2+ and PO 4 3− produced plaques, although smaller than those formed by injection of CaATP.
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