Abstract
Non‐small cell lung cancer (NSCLC) is generally insensitive to chemotherapy, and Antrodia cinnamomea (AC) has a long history used as a natural remedy for health improvement. The present study attempted to explore the anti‐cancer activity and mechanisms of the ethanolic extract of AC (EEAC) in human lung epithelial carcinoma A549 cell lines, a NSCLC cells. The results showed that EEAC treatment markedly decreased cell viability, arrested cell cycle in G0/G1 phase, and increased the activation of AMPK as well as downregulated the phosphorylation of Akt, mTOR, RB and ERK 1/2 proteins. Additionally, EEAC inhibited cell migration and reduced the expression level of matrix metalloproteinase (MMP)‐2 and 9 proteins. It has also noticed that EEAC can suppress the expression of Cav‐1 protein to enhance the chemotherapy sensitivity of A549 cells to paclitaxel. Our study suggested that EEAC might have potential activities to be developed as adjuvant remedy for lung cancer chemotherapy.
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