Abstract
Obesity is a serious health problem in industrialized countries because it is implicated in various diseases. In Current research, obesity of the human focus on intracellular triglyceride accumulation in adipocyte. These topics are discussed in relationship to the development of obesity. This study was performed to investigate the effects of Rubus coreanus and Morus alba on proliferation and adipocyte differentiation in 3T3‐L1 cells. Among the five fraction of Morus alba, hexan, chloroform, ethylacetate‐soluble fractions at concentrations of 100¥ìg/ml inhibited adipogenesis by 21.6, 23.9 and 38.5%, respectively. All of the fractions of Rubus coreanus extract attenuated intracellular lipid accumulation. Specially, ethylacetate‐soluble fraction of Rubus coreanus has the highest inhibitory effect on adipocyte differentiation as 86.8¥ìg/ml by IC50 value. On the other hands, Rubus coreanus and Morus alba ethanolic extracts inhibited preadipocyte proliferation and consequent differentiation within the first 3days of treatment. Rubus coreanus has the strongest anti‐proliferation effects on preadipocytes without cytotoxicity. These data indicate that the anti‐adipogenic effects of Rubus coreanus and Morus alba may derived from anti‐proliferation. From results, Rubus coreanus and Morus alba may prove to be valuable natural plant in the treatment of obesity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
