Abstract
The Angelicae dahuricae radix (ADR) has been used a traditional medicine to treat acne, erythema, headache, toothache, sinusitis, colds, and flu in Korea, Japan and China. Here, we report the effect of ADR on compound 48/80-induced ear-swelling and the phorbol myristate acetate (PMA) plus calcium ionophore A23187-induced inflammatory cytokine secretion in the human mast cell line, HMC-1. ADR dose-dependently inhibited the ear-swelling response induced by intradermal injection of compound 48/80, In vitro model, PMA plus A23187 significantly increased interleukin <TEX>$(IL)-1{\beta}$</TEX>, IL-8, granulocyte macrophage colony stimulating factor (GM-CSF), and tumor necrosis factor <TEX>$(TNF)-{\alpha}$</TEX> secretion compared with media control. We also show that the increased cytokines <TEX>$IL-1{\beta}$</TEX>, IL-8, GM-CSF, and <TEX>$TNF-{\alpha}$</TEX> level was significantly inhibited by treatment of ADR. In addition, ADR partially blocked PMA plus A23187-induced extracelluar signal-regulated kinases phosphorylation. These results suggest that ADR might explain its beneficial effect in the treatment of mast cell-mediated inflammatory diseases.
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