Abstract
The present paper reports the chemopreventive action of Dehydroepiandrosterone (DHEA) on Methylcholanthrene- (MCA) induced carcinogenesis in the uterine cervices of adult virgin Swiss albino mice. Placement of sterile double cotton thread impregnated with beeswax containing 600 μg of MCA in the cervical canal produced tumors in 85.7% of mice in 16 weeks. When such carcinogen-containing threads were inserted into the uterine cervices of mice that were being fed on diets of 0.025%, 0.05% and 0.1% DHEA for a period of two preinsertion and sixteen postinsertion weeks, the cervical tumor incidences were reduced to 59.0%, 34.7% (P < 0.01) and 14.2% (P < 0.01), respectively. It is inferred that DHEA inhibits MCA-induced cervical carcinogenesis and the inhibitory action is dependent upon the dose of the drug.
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