Abstract
Three teleost fishes, Carassius auratus, Gasterosteus aculeatus, and Cymatogaster aggregatus, have been injected for periods of about 4 weeks with a suspension of Methallibure (I.C.I. Compound 33,828). Although division of the primary germ cells continued, the gametogenetic processes of maturation were suspended in the gonads of both sexes of all three species. The brush border segments of the kidney tubules of Gasterosteus, a secondary sex character which increase in thickness under the influence of male gonadal hormones, remained in a state characteristic of immature fish; control animals showed changes characteristic of the breeding season. It is concluded that this compound blocks the action of pituitary gonadotropins on both the gametogenetic and the endocrine tissues of the testis.
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