Abstract
In a previous study, 1 phenylalanine (L-phenylalanine) was found to cause an inhibition of the immune response to diphtheria toxoid in rabbits and rats. Because phenylalanine interferes with the in vitro uptake of histidine, ornithine and tyrosine by the brain, 2 it appeared that phenylalanine may inhibit antibody synthesis by limiting the uptake and intracellular availability of essential amino acids. A reduction in availability of amino acids may be the ultimate cause of the decrease of antibody synthesis. The purpose of the present study was to analyze possible mechanisms of phenylalanine inhibition of the immune response and to determine if phenylalanine will inhibit the homograft reaction. Materials and Methods Amino Acid Analyses.— Twenty C57/HeJ mice were injected intraperitoneally with phenylalanine, 100 mg/day, for four days. The mice were killed by decapitation three hours after the last injection. The spleens were removed immediately, weighed, and frozen on solid carbon dioxide. The
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
