Abstract
An unique endogeneous digitalis-like factor (EDLF) has been previously purified from human newborn cord plasma and its differential effects tested on the three well defined functional isoforms (α1, α2and α3) of the alpha subunits of Na+/K+-ATPase in ratEDLF specifically inhibits the enzymatic activity. It differs from ouabain by three criteria: a preincubation with the membranes is required for full activity, no effect on the rat cerebral α3isoform and a steep dose-response curve with the same apparent potency for rat α2and α1isoforms of high (10-7M) and low affinity (3 × 10-5M) for ouabain. These results indicate that the Na+/K+-ATPase inhibitor involved in the regulation of sodium and body fluid volume and present in neonate and adult human plasmas is distinct from ouabain
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