Abstract
The in vitro antiviral activity of several 5-mercurithio analogs of 2′-deoxyuridine (dUrd) on the replication of herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) were examined. Of those compounds tested, the thioglycerol analog of 5-mercuri-2′-deoxyuridine (HgdUrd) was most effective in inhibiting the replication of HSV-1 in KB cells with a 50% inhibitory dose (ID 50) of 0.001 μg/ml while the glutathione analog of HgdUrd was the most effective in inhibiting the replication of HSV-2 with a ID 50 of 0.075 μg/ml. Conversely in HeLa TK − cells, the mercaptoguanosine analog of HgdUrd was the most effective compound in inhibiting virus replication with ID 50s of 0.098 and 0.001 μg/ml for HSV-1 and HSV-2 respectively. These results suggest that these mercurithio analogs of dUrd are as effective as acyclovir in preventing the replication of these herpesviruses.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
