Abstract
Streptozotocin-diabetic rats were fed a fructose based diet containing no added fat or equivalently absorbed doses of ethyl palmitate or ethyl linoleate. The hepatic lipogenic enzymes, fatty acid synthetase, malic enzyme, ATP-citrate lyase and glucose-6-phosphate dehydrogenase as well as hepatic lipogenesis measured in vivo were reduced in linoleate but not palmitate supplemented rats. Glucokinase and fructokinase were unaltered by linoleate or palmitate. These results show that insulin is not required for the inhibition of hepatic lipogenesis by dietary polyunsaturated fatty acids.
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