Abstract
Summary6-Deoxy-D-glucose has been shown to be an inhibitor of glucose oxidation in rat kidney slices, mouse adipose tissue, and rat diaphragm. The raio of 6-DOG to glucose which gave a 50% inhibition of glucose oxidation corresponded to 12:1 in rat kidney slices and rat diaphragm and 4:1 in mouse adipose tissue. The inhibition of glucose oxidation in mouse adipose tissue was shown to be reversible. Experiments using rat diaphragm tissue showed that 6-DOG inhibited uptake of glucose in proportion to decrease in glucose oxidation. Incubation of mouse adipose tissue with 6-DOG uniformly labeled with C14 did not result in formation of measurable amounts of C14O2. It is concluded that this compound is incapable of complete oxidation in this tissue. It is believed that the site of competitive inhibition is either at the cell entry mechanism or at the hexokinase reaction. Thus, the metabolic block produced by 6-DOG should be less complex than that produced by the 2-position modified sugars. The use of 6-DOG may ...
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
