Abstract
The effect on gastric secretion in the rat by small quantities of sodium oleate (7.5 and 15.0 mg.) has been investigated. It was found that intravenous or intraperitoneal administration of small amounts (0.25 cc. of 0.1 N solutions) decreased gastric secretion by one-third over a 4-hour period. Sodium propionate, sodium stearate, sodium linoleate, other fatty acids, and normal saline did not inhibit gastric secretion under identical conditions. We conclude, therefore, that Na oleate may have a specific pharmacologic effect on gastric secretion in the rat. Furthermore, this action is not predicated upon contact with the duodenal mucosa but rather a function of its presence in the bloodstream.
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