Inhibition of Calcium-dependent Protein Kinase 1 from Cryptosporidium parvum: An In-Silico Approach from Protein Modelling to Lead Compounds Identification for Cryptosporidiosis Treatment

Abstract

A year into the pandemic and there are still so many unknowns. There are very few specific answers about the origin of the virus, but this much is clear. It is not the last pandemic we will face, and far more dangerous pandemics await us in the future.Cryptosporidiosis can produce major epidemics whenever public health measures fails.Human cryptosporidiosis is a diarrheal disease mainly propagated by Cryptosporidium parvum (C. parvum) and Cryptosporidium hominis (C. hominis). It is a self-limited illness in immunocompetent patients but become a severe life-threatening illness in immunocompromised patients and children under five year of age. Several studies have explored the effects of cryptosporidiosis on the mortality rate of younger children. According to one research, about globally 30-50 % death of children of five years occurs due to cryptosporidiosisand is a second primary infection in 12- 13 months toddlers related with fatality. Although many attempts have been made to address this issue,it still lacks effective treatment options. The Nitazoxanide drug has shown moderate efficacy in immunocompetent patients.