Abstract
The binding of aldehydes derived from the biogenic amines (i.e. serotonin, dopamine, tryptamine, etc.) is dependent on the substituents attached to the carbonyl residue, as well as the aldehydic group per se. The hydroxyl group on the aromatic nucleus of “biogenic” aldehydes contributes significantly to the attachment of the moieties to brain tissue. Thus, 5-hydroxyindole and catechol were found to compete selectively with the “biogenic” aldehydes for tissue binding sites. The attachment of the “biogenic” aldehydes to tissue may also be prevented in vitro by various reducing or trapping agents, such as ascorbate, cysteine or glutathione. The possible physiologic significance of aldehyde binding to cellular components is discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
