Abstract
The effects of intracameral (i.c.) administration of MIF-I on the ocular response to α-MSH were tested in rabbits. In confirmation of previous studies, i.c. α-MSH significantly increased intraocular pressure (IOP) and reduced pupillary diameter (PD). Concomitant administration of α-MSH and MIF-I antagonized both the IOP increase and miosis induced by α-MSH. Aqueous humor (AH) dynamics studies revealed that α-MSH increases IOP, possibly, by decreasing AH outflow. The decreased AH outflow induced by α-MSH was antagonized by concurrent administration of MIF-I and α-MSH. MIF-I did not affect IOP or PD when administered alone. These results and more support for a role of α-MSH in ocular function, and suggest that the ocular response to α-MSH may be subject to inhibitory control by MIF-I.
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