Abstract
The effects of premedication with inhaled ipratropium bromide and fenoterol powders on heart rate and cardiac arrhythmias in patients undergoing bronchofibroscopy were evaluated in a double-blind, placebo-controlled study. Bronchoscopy induced significant sinus tachycardia in all patient groups, including smokers and nonsmokers ( P < 0.0001). The tachycardia was more pronounced in the patients treated with fenoterol compared with those receiving ipratropium bromide or placebo ( P < 0.05). The difference was largely attributable to the results obtained in the smokers. No life-threatening or other severe adverse effects were noted in any patient. Both fenoterol and ipratropium bromide can be administered safely as a premedication before bronchofibroscopy.
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