Abstract
Bronchial asthma is characterized by not only an increase in lung resistance but also inhomogeneous ventilation. We aimed to investigate how two inhalation anaesthetics, isoflurane and sevoflurane, relieve ventilation inhomogeneity and reduce lung resistance in the bronchoconstricted lung. We provoked bronchoconstriction in dogs by a continuous i.v. infusion of methacholine, then administered either isoflurane or sevoflurane. Ventilation inhomogeneity was quantified by the difference in respiratory phases between the regional alveolar pressures measured at two distinct lobes. We constructed a mathematical model that simulated our experimental results. Both anaesthetics decreased lung resistance (P < 0.01). Isoflurane significantly reduced the indices of inhomogeneity (P < 0.01). Sevoflurane exerted only a tendency to reduce uneven ventilation. Our model simulation suggested that the anaesthetics reduced ventilation inhomogeneity in preference to lung resistance when the dogs suffered from severe bronchoconstriction.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
