Abstract
Exposure to sweet substances has been shown to modify the analgesic effect of morphine. Presumably, this modification occurs because such exposure increases the level of endogenous opioids in the brain areas that mediate the analgesic properties of morphine. The present experiments were designed to test whether similar exposure affects morphine’s rewarding properties. Both acute (Experiment 1) and chronic (Experiment 2) exposures to sucrose solution were found to enhance the conditioned place preference produced by morphine. Thus, the level of endogenous opioids in brain areas that mediate the rewarding effect of morphine may also be increased by the ingestion of sweet substances.
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